Title : Breakthrough in Dementia
Alzheimer’s dementia is a neurodegenerative disorder that commonly affects the elderly was first described in 1906. Since then over a century researchers and medical professionals have made remarkable advances together with various organisations and fund providers in developing novel drugs and searching for a cure.
Alzheimer’s consists of two main pathologies extra-neuronal beta amyloid plaques deposits and intra-neuronal breakdown of individual neuron due to abnormal tau protein. There are other postulates like deposition of magnetic iron oxide, immune mediated process and even Human Herpes virus infection having a part in the pathogenesis of Alzheimer’s dementia.
Many developed countries commonly practice the identification biomarkers such as Tau and Beta-amyloid proteins in CSF, identifying high risk gene like APOE4, functional neuroimaging rather than based on mere history. This will aid in making early diagnosis before the destruction of neurons, track the disease progression and monitor treatment effects especially in clinical trials of disease-modifying drugs.
Numerous clinical trial had been conducted to find a cure for Alzheimer’s dementia but unfortunately all turned out to be not suitable. Most recently dementia prevention study using antibodies to beta amyloid and tau protein are being carried out but awaiting for the results which will be out in 2 to 5 years’ time. There are still many Phase I, Phase II and Phase III studies ongoing and hope to see a breakthrough in the drug therapy for dementia.
Meanwhile it is vital to stay healthy embracing healthy lifestyle with proper diet control, exercising regularly, remain cognitively stimulated and managing the metabolic and vascular risk factors well which had shown positive cognitive outcome.
What will audience learn from your presentation?
• The progress that had come through since the terminology Alzheimer’s Disease came into place since 1906.
• Developments made in the etiology, diagnosis and treatment evolved, yet adopting healthy life style is vital for everyone.