Abstract:Overnutrition and modern diets containing high proportions of saturated fat are amongst the major factors responsible for the development of low-grade, systemic, chronic inflammation, hyperglycaemia and dyslipidaemia. These conditions may eventually lead to insulin resis [....] » Read More
Abstract: In the brain, small pial arteries and arterioles with diameters up to 100-150 microns is the primary regulator of local tissue perfusion for the delivery of oxygen and nutrients to meet the metabolic demands from neurons and other cells. Recently, cerebral lympha [....] » Read More
Alzheimer’s disease (AD) and AD-related dementias (ADRD) are the common incurable neurodegenerative conditions characterized by progressive cognitive deterioration, memory decline and even death. The major forms of ADRD include vascular contributions to cognitive impai [....] » Read More
Alzheimer’s dementia is a neurodegenerative disorder that commonly affects the elderly was first described in 1906. Since then over a century researchers and medical professionals have made remarkable advances together with various organisations and fund providers in develo [....] » Read More
Memory decline and impairments occur predominantly in people with dementia (PWD). Deficits in episodic and verbal short-term memory (vSTM) have been widely reported in PWD. Analysis of spoken spontaneous discourse is becoming more popular in dementia research as well as clinical [....] » Read More
Malaysia is rapidly ageing with declining number of younger age groups and the young old surpassing the other older groups. As dementia is a age related neuro-degenerative disease of the brain, more and more older people will be inflicted with dementia and this silent epidemic wi [....] » Read More
Neuroinflammation is a hallmark of Alzheimer’s disease (AD). Microglia are the resident immune cells in the central nerves system (CNS) and function in many aspects of neuroinflammation. The immune functions of microglia such as surveillance and clearance are gradually lost [....] » Read More
Coronavirus disease 2019 (COVID-19) is a multi-organ and multi-system disease, associated with high morbidity and mortality due to pulmonary and cardiovascular involvement, and attended by various neurological and psychiatric (N and P) manifestations during its acute and subseque [....] » Read More
In late 2019, the world was introduced to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathogen, a strain of the coronavirus which has caused the respiratory illness termed Covid-19 (coronavirus 2019; Wong, 2021). At the time of writing, there has been a repor [....] » Read More
Mitophagy and mitochondrial dynamics alterations are two major hallmarks of neurodegenerative diseases. Dysfunctional mitochondria accumulate in Alzheimer’s diseaseaffected brains by yet unexplained mechanisms We show that presenilins 1 and 2 trigger opposite e [....] » Read More
Neurodegenerative diseases associated to aging are one of the most important social, human, family and economic problems of this century, whose etiology, pathology, early symptoms and evolution are not well known. Therefore, the development and application of new methodologies ar [....] » Read More
The myelin sheaths that cover the axons are essential for the conduction of nerve impulses in the nervous system. In this regard, mature oligodendrocytes are the myelinating cells of the central nervous system (CNS). In recent decades, research on the mechanisms involved in myeli [....] » Read More
Epidemiological evidence suggests air pollution exposure may increase risk of Alzheimer’s disease and related dementias (ADRD). However, previous U.S. studies have predominantly focused on hospitalizations, which fails to fully capture ADRD. Here we constructed two national [....] » Read More
Abstract: We have previously reported that the dUTPase protein from human herpesvirus 6A (HHV-6A) and Epstein-Barr virus (EBV) increased the expression and secretion of pro-inflammatory cytokines from hDCs in a TLR2-dependent manner. Because IL-1β and IL-6 can disrupt the [....] » Read More
Cognitive impairment is a core feature of cyclin-dependent kinase-like 5 (CDKL5) deficiency, a neurodevelopmental disorder characterized by early epileptic seizures, intellectual disability, and autistic behaviors. Although loss of CDKL5 affects a number of molecular pathways, ve [....] » Read More
Alzheimer's disease (AD), a main cause of dementia is known to have a strong genetic component to its development and is often comorbid with neuropsychiatric conditions. In addition, certain neuropsychiatric disorders are considered as early indicators of AD and present when [....] » Read More
Alzheimer's disease is a progressive degenerative disease commonly seen in the elderly. Symptoms of this disease include memory loss, judgment and important behavioral changes in the person. The main purpose and motivation of this study was to design and present a model for t [....] » Read More
Abstract: Sporadic (late-onset) Alzheimer’s disease (sAD) is a progressive neurodegenerative age-related disease, caused by interaction of genetic and environmental factors, leading to brain damage accompanied by memory loss and cognitive impairment. Up till now, animal- [....] » Read More
Title : Can we stimulate neuroplasticity with the cell signaling molecule ghrelin?
Irina Stoyanova, Medical University of Varna, Bulgaria
The increase in human lifespan during the last century is accompanied by an increased risk for development of age-related disorders including neurodegenerative diseases (NDD) such as Alzheimer’s and Parkinson’s disease. These pathologies are characterised by impairmen [....] » Read More
Title : Sleep quality improvement for Alzheimer’s disease
Benyi Li, University of Kansas, United States
Abstract: Alzheimer’s disease (AD) is a progressive neuronal degenerative disorder and sleep disorders have been linked to Alzheimer’s disease progression in addition to the typical symptoms of progressive loss of memory, speech, and cognition. Sleep behaviour changes [....] » Read More
Title : Implications for Serum Amyloid P in the Pathogenesis of Alzheimer’s Disease
Mark S Kindy, University of South Florida and the James A. Haley VA Hospital, United States
Serum amyloid P component (SAP) is found in all amyloids and studies have suggested that it plays an integral role in the formation, progression, and maintenance of the disease processes. The mouse SAP (mSAP) does not interact with human proteins and since most of the models for [....] » Read More
Title : Computational models and biophysics for understanding neuronal dysfunctions in Alzheimer’s disease
Don Kulasiri, Lincoln University, New Zealand
Alzheimer’s disease (AD) as the leading cause of dementia affects millions of families across the world. AD causes huge physical social, psychological and financial impacts not only on the patients but also on their families and the whole society. Numerous research has been [....] » Read More
Title : Novel Pharmacological Targets of Alzheimer’s Disease
Yung-Feng Liao, Academia Sinica, Taiwan
Alzheimer's disease (AD) is characterized by a chronic decline in cognitive function and is pathologically typified by cerebral deposition of amyloid-β peptide (Aβ). The production of Aβ is mediated by sequential proteolysis of amyloid precursor protein (APP) b [....] » Read More
Title : Cognitive and psychological vulnerability in developing Dementia - a comparative study of Paid Institutional, Free Institutional and Residential care!
Ravi Samuel, The Psychotherapy Clinic, India
The prevalence of Dementia is on the rise due to increasing longevity. In addition, co-morbid medical conditions and depression lead to the onset of cognitive impairment - the prevalence of medical ailments like diabetes mellitus, hypertension, and depression are high among the e [....] » Read More
Title : Computational models and biophysics for understanding neuronal dysfunctions in Alzheimer’s disease
Jingyi Liang, UiT The Arctic University of Norway, Norway
Alzheimer’s disease (AD) as the leading cause of dementia affects millions of families across the world. AD causes huge physical social, psychological and financial impacts not only on the patients but also on their families and the whole society. Numerous research has been [....] » Read More
Title : Lead toxicity associated protein and its role in Alzheimers Disease & Dementia in industrial workers
Shubhangi Pingle, Regional Occupational Health Centre (Southern), NIOH, India
The interaction between proteomic profiling and Alzheimer's disease, Dementia in industrial workers was not explored in occupational settings. Therefore, the present study, aimed to assess the proteomic profiling with among workers exposed to Pb with contemplation of varied b [....] » Read More
Title : Mitochondria and Alzheimer’s disease: Participation of Miro protein
Anand Krishna Tiwari, Institute of Advanced Research, India
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized by loss of memory and cognitive impairment due to the accumulation amyloid beta 42 (Aβ42) plaque and neurofibrillary tangles (NFT) due the hyperphosphorylated Tau protein in the parts of brain. Due [....] » Read More
Title : Cellular Polyamines Condense Hyperphosphorylated Tau Triggering Alzheimer’s Disease
Stefan Milanov Ivanov, Redesign Science, United States
Many gaps in our understanding of Alzheimer’s disease (AD) remain despite intense research efforts. Perhaps the most prominent gap is the mechanism of tau condensation and fibrillization. One viewpoint is that positively charged tau is condensed by cytosolic polyanions. How [....] » Read More
Title : Effects of caffeine ingestion on psychomotor state and oxidative stress markers after an 8-km run competition in sleep-deprived recreational runners
Amir Khcharem, University of Sfax, Tunisia
Background: Various pharmacological aids are used to counteract the detrimental effects of sleep loss on exercise, such as caffeine. However, studies examining the possible protective impact of caffeine against reactive oxygen species (ROS) at the level of cell and tissue culture [....] » Read More
Title : Neuroprotective Mechanisms of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer’s Disease
Leila Hosseini, Tabriz University of Medical Sciences, Iran (Islamic Republic of)
Abstract: In the current aging society, the number of patients suffering from Alzheimer’s disease (AD) is rapidly increasing, and without therapeutic breakthroughs is estimated to reach 80 million by 2040. As an irreversible chronic neurodegenerative disease, AD is chara [....] » Read More
Title : Galanin and Neuropeptide Y interaction enhances proliferation of granule precursor cells and expression of neuroprotective factors in the rat hippocampus with consequent augmented spatial memory
Manuel Narváez Peláez, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Spain
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for Neuropeptide Y (NPY) and galanin (GAL) interaction was show [....] » Read More
Title : Photobiomodulation and Taurine in Human Neuroblastoma: In vitro study of Alzheimer's disease
Cristina Pacheco Soares, Universidade do Vale do Paraiba, Brazil
The limited repair capacity of the central nervous system (CNS) is a viable challenge. Alzheimer's disease (AD) is a progressive and highly prevalent neurodegenerative disease that affects people worldwide. The complete inclusion of the CNS is not yet possible by m [....] » Read More
Title : Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of Alzheimer’s disease
Claudia Colussi, Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti" (IASI) , Italy
Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), leading to progressive memory loss and cognitive decline. The nucleoporin Nup153, besides its role in nuclear transport, has been described as a key regulator of NSC plastici [....] » Read More
Title : Utilizing feature selection to identify proteomic biomarkers for support vector machine learning-based classification of Alzheimer’s disease
Kesheng Wang, West Virginia University, United States
Background: Proteins play an important role in disease pathways and drug-target discovery. The most widely used biomarkers for Alzheimer’s disease (AD) include the apolipoprotein E (APOE) protein, the clinical cerebrospinal fluid (CSF) protein biomarkers of Aβ plaques [....] » Read More
Title : White Matter integrity and key structures affected in Alzheimer’s disease based on diffusion tensor imaging
Danqing Xiao, Regis College, United States
White matter (WM) degeneration is suggested to predict the early signs of Alzheimer disease (AD). The exact structure regions of brain circuitry involved is not clear. This study aims to examine the associations between WM tract integrity, specifically the specific diffusion tens [....] » Read More
Title : Pathogenic ?-synuclein cell-to-cell transmission mechanism and related therapeutic development
Xiaobo Mao, Johns Hopkins School of Medicine, United States
α-Synucleinopathies is characterized with accumulation of misfolded α-synuclein (α-syn), including Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB), and Multiple System Atrophy (MSA). Emerging evidence indicates that pathogenesis of α-synucl [....] » Read More
Title : Characterization of a New molecules’ inhibitor effect on Alzheimer’s Disease Amyloid-Beta Peptides Cascade
Subramanian Boopathi, Universidad Nacional Autónoma de México, Mexico
Over 50 million people succumbed to Alzheimer’s disease (AD) worldwide. Unless scientists predict effective therapeutic strategies, this number will reach 150 million by 2050. AD is characterized by progressive neurodegeneration associated with Amyloid β (Aβ) [....] » Read More