HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
Speaker at International Alzheimer’s Disease & Dementia Conference 2022 - Jun Hua
Johns Hopkins University School of Medicine, United States
Title : Impaired small vessels in neurodegenerative diseases


In the brain, small pial arteries and arterioles with diameters up to 100-150 microns is the primary regulator of local tissue perfusion for the delivery of oxygen and nutrients to meet the metabolic demands from neurons and other cells. Recently, cerebral lymphatic vessels have been identified in the dura mater alongside blood vessels in the brain. These small vessels are believed to be a critical component of the central nervous system (CNS) as a waste clearance pathway for the cerebrospinal fluid (CSF) and interstitial fluid (ISF), which may play a crucial role in many brain diseases. In this talk, I will first describe advanced MRI techniques that we developed for imaging small blood and lymphatic vessels in the brain. I will then discuss the application of these MRI techniques in several brain diseases to study associated neurovascular abnormalities.

What will audience learn from your presentation?

  • Advanced MRI techniques for imaging small vessels in the brain; Small blood vessel abnormalities in brain diseases; Impaired cerebral lymphatic vessels in brain diseases
  • Abnormalities in small blood and lymphatic vessels are commonly seen in brain disorders. Noninvasive imaging techniques can provide sensitive and specific information about such abnormalities which can be used as potential biomarkers for tracking disease progression as well as potential treatment targets for the development of novel therapeutic interventions.


Hua received his master's (2005) and doctoral (2009) degrees in biomedical engineering and electrical engineering at the Johns Hopkins University. His doctoral training centered on the development of novel MRI technologies for in vivo physiological imaging in the brain, such as protein content and cerebral blood volume.

After completing a post-doctoral fellowship in the Department of Radiology at the Johns Hopkins University from 2009 to 2010, Dr. Hua became a faculty member in the Department of Radiology at Johns Hopkins University School of Medicine and Kennedy Krieger Institute.