Title : Impaired small vessels in neurodegenerative diseases
Abstract:
Abstract:
In the brain, small pial arteries and arterioles with diameters up to 100-150 microns is the primary regulator of local tissue perfusion for the delivery of oxygen and nutrients to meet the metabolic demands from neurons and other cells. Recently, cerebral lymphatic vessels have been identified in the dura mater alongside blood vessels in the brain. These small vessels are believed to be a critical component of the central nervous system (CNS) as a waste clearance pathway for the cerebrospinal fluid (CSF) and interstitial fluid (ISF), which may play a crucial role in many brain diseases. In this talk, I will first describe advanced MRI techniques that we developed for imaging small blood and lymphatic vessels in the brain. I will then discuss the application of these MRI techniques in several brain diseases to study associated neurovascular abnormalities.
What will audience learn from your presentation?
- Advanced MRI techniques for imaging small vessels in the brain; Small blood vessel abnormalities in brain diseases; Impaired cerebral lymphatic vessels in brain diseases
- Abnormalities in small blood and lymphatic vessels are commonly seen in brain disorders. Noninvasive imaging techniques can provide sensitive and specific information about such abnormalities which can be used as potential biomarkers for tracking disease progression as well as potential treatment targets for the development of novel therapeutic interventions.
