Shubhangi Pingle

Title : Lead toxicity associated protein and its role in Alzheimers Disease & Dementia in industrial workers

Abstract:

The interaction between proteomic profiling and Alzheimer's disease, Dementia in industrial workers was not explored in occupational settings. Therefore, the present study, aimed to assess the proteomic profiling with among workers exposed to Pb with contemplation of varied blood lead levels and duration of exposure.

The study on the serum markers with reference to lead toxicity is limited in human beings. The obtained protein markers can be correlated with the exposure pattern and can have a broad range of potential applications. They may be used for clinical diagnostic or prognostic purposes like Alzheimer's disease and Dementia. The novel mechanistic links between lead exposure and protein expression can be evaluated. The earlier studies were conducted on common effect of heavy metals and does not covered about specific lead toxicity on proteomic profile. This is different pursuit in which the interaction between Alzheimer's disease, Dementia and proteomic profiling will be explored in occupational settings.

Assessment of proteomic profiling in occupational lead exposures settings will identify the functional classification and protein – protein interactions. It also highlights the interaction between Alzheimer's disease, Dementia and proteomic profiling among lead exposed workers.

What will audience learn from your presentation?

The study on the serum markers with reference to lead toxicity is limited to human beings. The obtained protein markers can be correlated with the exposure pattern and can have a broad range of potential applications. They may be used for clinical diagnostic or prognostic purposes. The novel mechanistic links between lead exposure and protein expression can be evaluated. The earlier studies were conducted on the common effects of heavy metals and do not cover specific lead toxicity on proteomic profile. This is a different pursuit in which the interaction between proteomic profiling and Alzheimer's disease, Dementia in industrial workers will be explored in occupational settings.

Biography:

Dr. Shubhangi Pingle graduated, post-graduated and obtained her doctorate from RTM Nagpur University. She is Scientist D, ROHC, NIOH Banglore, ICMR, India. She Published 110 research papers in National and International journals. She acquired 15 years of research experience in proteomics, Diagnostic Biomarkers, Development of ELISA and Animal cell culture biology.  She has three Indian Patent granted and 6 submitted. She completed projects cost around ~US$ 3 million. She implemented many areas first time  in the diagnostic field of research by her differing approach. She has expertise in preventive measures of occupational health diseases used for beneficiation of industry workers.