HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
Speaker at International Alzheimer’s Disease & Dementia Conference 2022 - Benyi Li
University of Kansas, United States
Title : Sleep quality improvement for Alzheimer’s disease


Abstract: Alzheimer’s disease (AD) is a progressive neuronal degenerative disorder and sleep disorders have been linked to Alzheimer’s disease progression in addition to the typical symptoms of progressive loss of memory, speech, and cognition. Sleep behaviour changes often began in the prodromal phase of Alzheimer’s disease, while patients only suffered from mild cognitive impairment. In animal studies, sleep deprivation or disturbances promoted brain pathologies related to Alzheimer’s disease. Interestingly, sleep treatment with continuous positive airway pressure in SDB patients improved cognition scores in patients with Alzheimer’s disease, indicating a bidirectional relationship between sleep disorders and Alzheimer’s disease. In a groups of mild-moderate cognition patients due to Alzheimer’s disease with sleep-disordered breathing, a complete recovery of sleep quality was achieved with improved recognition and reduced anxiety after a 6-month treatment. Our study provided the first evidence that sleep intervention is feasible to improve neuropsychological symptoms and reduce disease progression when implicated in the early phase of Alzheimer’s disease.

What will audience learn from your presentation?

  • Sleep intervention is feasible to improve neuropsychological symptoms and reduce disease progression in the early phase of Alzheimer’s disease
  • First clinical study of the relationship between sleep intervention and Alzheimer’s disease
  • This study will open a new field of clinical study for sleep improvement in Dementia patients.
  • This talk will open a new field of sleep monitoring in Dementia patients with advanced imaging technology.


I received my medical education in China and my Ph.D. work in Japan. After moved to the US in 1998, I stayed away from clinical work but focused on urological research. After 2 postdoc fellowships at Moffitt Cancer Center and Baylor College of Medicine, I joined the KUMC Urology faculty at the end of 2001 and established the basic research program for the department. My research topic is mainly on prostate cancer, aiming to develop novel and clinically beneficial therapeutics for patients with advanced prostate cancers.