Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Neurovascular abnormalities play a critical role in the pathogenesis of neurodegenerative diseases. Impaired small blood vessels and CSF clearance through cerebral lymphatic vessels are often observed in such diseases. Noninvasive imaging biomarkers can provide a powerful tool for diagnosing the diseases, monitoring the progression, and evaluating potential therapeutics. In this talk, I will first describe recent development of MRI techniques for imaging small blood and lymphatic vessels in the brain. I will then discuss the application of these MRI techniques in several brain diseases to develop imaging based biomarkers associated neurovascular abnormalities.