Jun Hua

Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases

Abstract:

Neurovascular abnormalities play a critical role in the pathogenesis of neurodegenerative diseases. Impaired small blood vessels and CSF clearance through cerebral lymphatic vessels are often observed in such diseases. Noninvasive imaging biomarkers can provide a powerful tool for diagnosing the diseases, monitoring the progression, and evaluating potential therapeutics. In this talk, I will first describe recent development of MRI techniques for imaging small blood and lymphatic vessels in the brain. I will then discuss the application of these MRI techniques in several brain diseases to develop imaging based biomarkers associated neurovascular abnormalities.

Biography:

Hua received his master's (2005) and doctoral (2009) degrees in biomedical engineering and electrical engineering at the Johns Hopkins University. His doctoral training centered on the development of novel MRI technologies for in vivo physiological imaging in the brain, such as protein content and cerebral blood volume.After completing a post-doctoral fellowship in the Department of Radiology at the Johns Hopkins University from 2009 to 2010, Dr. Hua became a faculty member in the Department of Radiology at Johns Hopkins University School of Medicine and Kennedy Krieger Institute.