Jun Hua

Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases

Abstract:

Neurovascular abnormalities play a critical role in the pathogenesis of neurodegenerative diseases. Impaired small blood vessels and CSF clearance through cerebral lymphatic vessels are often observed in such diseases. Noninvasive imaging biomarkers can provide a powerful tool for diagnosing the diseases, monitoring the progression, and evaluating potential therapeutics. In this talk, I will first describe recent development of MRI techniques for imaging small blood and lymphatic vessels in the brain. I will then discuss the application of these MRI techniques in several brain diseases to develop imaging based biomarkers associated neurovascular abnormalities.

Biography:

Dr. Hua is a Professor in the F.M. Kirby center at Kennedy Krieger Institute and in the Department of Radiology at Johns Hopkins Medical School. His research has centered on the development of novel MRI technologies for in vivo functional and physiological imaging in the brain, and the application of such methods for studies in healthy and diseased brains.