For effective treatment and prevention of dementia, it is important to develop an objective, accurate, and inexpensive screening test for early diagnosis of cognitive impairment. To resolve these issues, we have developed a deep neural network (DNN) model that can estimate risk o [....] » Read More
Overnutrition and modern diets containing high proportions of saturated fat are amongst the major factors responsible for the development of low-grade, systemic, chronic inflammation, dyslipidaemia and hyperglycaemia. Interestingly enough, recent studies started to recognize oxid [....] » Read More
Neurovascular abnormalities play a critical role in the pathogenesis of neurodegenerative diseases. Impaired small blood vessels and CSF clearance through cerebral lymphatic vessels are often observed in such diseases. Noninvasive imaging biomarkers can provide a powerful tool fo [....] » Read More
Background: Corticobasal degeneration (CBD) is a rare neurodegenerative tauopathy primarily affecting the cerebral cortex and basal ganglia, often featuring cognitive decline and parkinsonism. With no proven treatments, management goals include improving patients' quality [....] » Read More
There are around 35 million individuals affected by Alzheimer’s disease (AD) dementia worldwide, and currently there are no effective disease-modifying medicines for AD. During the last 2.5 decades, four FDA-approved AD drugs, i.e., donepezil, rivastigmine, galantamine, and [....] » Read More
The behavioural phenotype research can be of great importance as the first symptom of neurodegenerative disorders is often identifiable through subtle changes in day-to-day human behaviors. Because of the similarity and homology between humans and mice, modelling mouse behaviour [....] » Read More
As GPs and Menopause Specialists brain fog is a frequent topic and often the most distressing and debilitating symptom expressed in consultation. It can present in a way that we don’t recognise and the diagnosis is too easily missed. It can present in primary care, neurolog [....] » Read More
The degree of brain entropy (BEN) is associated with different levels of consciousness. The entropic brain hypothesis contemplates that, within upper and lower cutoff points, beyond which consciousness may be significantly reduced or absent, the entropy of spontaneous cerebral ac [....] » Read More
Objective: We aimed to analyze the discriminative power of a culture-free Go/No-Go task by comparing three groups: cognitively unimpaired healthy elderly, Mild Cognitive Impaired subjects (MCI), and early Alzheimer´s disease patients (AD). For the three groups th [....] » Read More
Type 2 diabetes (T2D) is a chronic metabolic disorder that significantly increases the risk of dementia, particularly Alzheimer’s disease (AD). It is of utmost importance to decipher the mechanisms underlying T2D-associated brain damage to facilitate the development of effe [....] » Read More
Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of essential cell functions including autophagy. mTOR primarily governs cell growth in response to favorable n [....] » Read More
Alzheimer’s disease (AD) is the most common form of dementia without effective clinical treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD-like pathology in a transgenic AD mouse model (5XFAD). IF alters gut microbial composition wit [....] » Read More
Sleep disorders are commonly found in Alzheimer's disease (AD) patients, which can occur at very early stage of AD and are proposed as potent risk factors for disease onset and progression. What may cause these early-onset sleep deficits remains unexplored. Here by thoroughly [....] » Read More
Background: Early detection of dementia is very important for improving the quality of life of patients and their families and providing appropriate medical interventions. The Korean Dementia Screening Questionnaire (KDSQ) was developed by Dong Won Yang et al. in 2002 and is used [....] » Read More
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Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Alzheimer’s disease (AD) and AD-related dementias (ADRD) are the common incurable neurodegenerative conditions characterized by progressive cognitive deterioration, memory decline and even death. The major forms of ADRD include vascular contributions to cognitive impai [....] » Read More
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
The NICE guidelines in November 2006 stated: "People with mild / moderate dementia of all types should be given the opportunity to participate in a structured group cognitive stimulation programme. This should be commissioned and provided by a range of health and social c [....] » Read More
Title : Aging in place with dementia: Strategies for successfully aging in place
Denise Dupree, Homewatch Care Givers of ST Pete Beach, United States
Aging in place is the term used to describe seniors who are able to live independently in their own homes for as long as possible. The reasons for aging in place vary from individual to individual. Some seniors want to remain active and independent in their own home for as long a [....] » Read More
Title : Closing gaps by addressing racial & ethnic disparities in Alzheimer’s disease and reducing the cost and risk of dementia in diverse communities
Constantina Mizis, The Latino Alzheimer’s and Memory Disorders Alliance, United States
Statement of the Problem: More than 5 million of Americans are living with Alzheimer’s, and that number is expected to increase to 14 million in 2050. According to UsAgainstAlz., Alzheimer’s will cost Latino families a cumulative $2.3 trillion by 2060 and the number o [....] » Read More
Title : Use of highly enhanced autologous natural killer cells for advanced Alzheimer’s disease
Paul Y Song, NKGen Biotech, United States
Background: Alzheimer’s Disease (AD) remains a neurodegenerative diseases with little to no disease modifying treatments. As more evidence emerges on how misfolded amyloid deposits elicit a cascade of autoreactive neuroinflammation and damage, it is clear that removing thes [....] » Read More
Title : Efficacy and safety of transcranial pulse stimulation (TPS) in older adults with mild neurocognitive disorder – An open-label trial
Cheng Pak Wing Calvin, The University of Hong Kong, Hong Kong
There are limited effectiveness and potential alarming side effects of pharmacological approach for the Neurocognitive disorder (NCD). Transcranial pulse stimulation (TPS) has been shown to be a potential tool to bring the benefit. We have conducted an open-label study. Older adu [....] » Read More
Title : The relevance of family involvement in the journey of dementia patients
Akankunda Veronicah, Executive Director, Uganda
Dementia is an age mental disorder that makes victims lose normal functionality that need delicate attention. It has been technically defined as a clinical syndrome characterised by a cluster of symptoms manifested by difficulties in memory, disturbances in speech and a [....] » Read More