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Speaker at Alzheimer’s Disease & Dementia Conference 2023 - Bitra Veera Raghavulu
University of Botswana, Botswana
Title : mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis

Abstract:

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of essential cell functions including autophagy. mTOR primarily governs cell growth in response to favorable nutrients and other growth stimuli. However, it also influences aging and other aspects of nutrient-related physiology such as protein synthesis, ribosome biogenesis, and cell proliferation in adults with very limited growth. The major processes for survival such as synaptic plasticity, memory storage and neuronal recovery involve a significant mTOR activity. mTOR dysregulation is becoming a prevalent motif in a variety of human diseases, including cancer, neurological disorders, and other metabolic syndromes. The use of rapamycin to prolong life in different animal models may be attributable to the multiple roles played by mTOR signaling in various processes involved in ageing, protein translation, autophagy, stem cell pool turnover, inflammation, and cellular senescence. mTOR activity was found to be altered in AD brains and rodent models, supporting the notion that aberrant mTOR activity is one of the key events contributing to the onset and progression of AD hallmarks.

Key words: mTOR; Alzheimer’s disease; Rapamycin; Macroautophagy; Apoptosis; Cognition.

Biography:

Veera Raghavulu Bitra, a Senior Lecturer at the School of Pharmacy, Faculty of Health Sciences at the University of Botswana. He holds a Doctor of Philosophy degree from Andhra University, India, a Master of Pharmacy degree from Sri Ramachandra University, India, and a Bachelor of Pharmacy degree from The Tamil Nadu Dr. MGR Medical University, India.

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