Title : Association between the triglyceride glucose-body mass index and memory-related diseases: A nationwide cohort study
Abstract:
Background: This study aimed to examine the longitudinal association between the triglyceride glucose-body mass index (TyG-BMI) index and memory-related diseases (MDs) among Chinese adults.
Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), which is an ongoing nationally representative prospective cohort study. The exposure was the participants' TyG-BMI index at baseline from 2011 to 2012. MDs were acquired by self-reporting questions in 2018. Cox proportional hazards regression models were conducted to assess the relationship between the TyG-BMI index and MDs.
Results: During a median follow-up of 7.0 years, a total of 197 incident MDs events occurred. After multivariate adjustments for established MD-related risk factors, participants with the highest tertile of the TyG-BMI index had a higher risk of MDs (HR: 1.65; 95% CI: 1.02-2.09; P-trend < 0.001) relative to individuals with the lowest tertile. Furthermore, the subgroup analyses of the association remained consistent.
Conclusion: A high TyG-BMI index was associated with an increased risk of MDs. Our study suggests that monitoring long-term changes in the TyG-BMI index could assist with the early identification and prevention of MDs among individuals at high risk.
Keywords: TyG-BMI index; Memory-related diseases; CHARLS; Cohort study; Risk factor
