Alzheimer's disease (AD) is a chronic neurological condition that is regarded as one of the most challenging medical problems to treat, with significant societal and economic consequences. The number of persons living with Alzheimer's disease (AD) in the United States is increasing. Drug discovery in stages of Alzheimer's disease before symptomatic dementia, such as preclinical AD, has resulted from significant research investment. There are now six phase 3 clinical trials for preclinical AD treatments, despite the fact that no medicines for preclinical AD have been approved.
Despite decades of preclinical research to better understand the disease and uncover treatment targets, Alzheimer's disease remains incurable. The challenge is being met with new methods of thinking about a number of animal models. Alzheimer's disease (AD) experimental models are essential for better understanding aetiology and evaluating the efficacy of innovative therapy approaches. Transgenic mice that overexpress human genes linked to familial Alzheimer's disease (FAD) and generate amyloid plaques are the most extensively utilized experimental animal models.
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Him, that person and me
Simon C Barton, Stroke Survivor, United States
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States