Psychotic depression, also known as major depressive disorder with psychotic elements, is a serious condition that necessitates rapid medical or mental health therapy and thorough monitoring. Major depressive disorder (MDD) is a prevalent mental illness that can have a detrimental impact on many aspects of a person's life. It has an effect on mood and behavior, as well as physical functions such as eating and sleep. People suffering from serious depression frequently lose interest in activities they formerly enjoyed and have difficulty carrying out daily tasks. They may even believe that life isn't worth living at times. Depression and psychosis affect approximately 30 to 50 percent of Alzheimer's patients (AD). Grief and moderate depressed symptoms to serious depression are all examples of depressive syndromes. Depression, sometimes known as dementia syndrome of depression, can resemble the signs and symptoms of Alzheimer's disease. Paranoid delusions, misidentification syndrome, and hallucinations are examples of psychotic syndromes. A detailed history and a mental state examination are used to diagnose depression and psychosis.