β and p-tau have been proven to predict disease progression independently in various investigations. Both proteinopathies, according to a hypothesised framework, synergistically enhance downstream neurodegeneration. The presence of such a synergism would imply that the combined effect of A β and p-tau on AD progression is greater than the sum of their individual effects at the same level. Indeed, recent studies demonstrate that rather than neurodegeneration, the synergistic interaction between brain A and p-tau drives AD-related metabolic decline in a cognitively normal population. In the adult human brain, billions of synapses join more than a hundred billion long branching extensions of neurons to build complex chemical connections between inter-neuron circuits. Nonlinear cumulative effects of two active chemicals with similar or related consequences of their distinct activities, or active compounds with sequential or complementary activities, are known as synergistic effects.
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Him, that person and me
Simon C Barton, Stroke Survivor, United States
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States