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Synergistic Mechanism and Effects on Progression

β and p-tau have been proven to predict disease progression independently in various investigations. Both proteinopathies, according to a hypothesised framework, synergistically enhance downstream neurodegeneration. The presence of such a synergism would imply that the combined effect of A β and p-tau on AD progression is greater than the sum of their individual effects at the same level. Indeed, recent studies demonstrate that rather than neurodegeneration, the synergistic interaction between brain A and p-tau drives AD-related metabolic decline in a cognitively normal population. In the adult human brain, billions of synapses join more than a hundred billion long branching extensions of neurons to build complex chemical connections between inter-neuron circuits. Nonlinear cumulative effects of two active chemicals with similar or related consequences of their distinct activities, or active compounds with sequential or complementary activities, are known as synergistic effects.

  • Disease Prognosis
  • Synergy Between Amyloid-Β And Tau in Alzheimer's Disease
Committee Members
Speaker at Alzheimer’s Disease & Dementia Conference 2023 - Yong-Xiao Wang

Yong-Xiao Wang

Albany Medical College, United States
Speaker at Alzheimer’s Disease & Dementia Conference 2023 - Kaoru Sakatani

Kaoru Sakatani

The University of Tokyo, Japan
Speaker at Alzheimer’s Disease & Dementia Conference 2023 - Jun Hua

Jun Hua

Johns Hopkins University School of Medicine, United States

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