Different motor abilities are derived from the coordinated activity of various motor control systems present throughout the brain and spinal cord, as well as those that extend via the peripheral nervous system to musculoskeletal tissues. Multiple interrelated cortical and subcortical motor areas contain motor control systems that regulate the beginning, planning, and execution of motor performances. These supraspinal motor systems can influence spinal motor systems that directly regulate muscle, the final effector of all movement, owing to descending white matter tracts. According to numerous researches, motor signs (MOSIs) are widespread in Alzheimer's disease (AD) and that their frequency and severity grow over time. These MOSIs may be caused by a variety of underlying causes, and while they are commonly thought to be caused by pathologic alterations in the extrapyramidal system, their exact anatomic location is unknown.