Alzheimer's disease, a form of dementia, has a significant genetic component. While age remains the greatest risk factor, several genes play roles in its development. The APOE gene, particularly the ε4 allele, increases susceptibility, influencing the age of onset and progression. Mutations in genes like APP, PSEN1, and PSEN2 are linked to rare, early-onset familial forms of Alzheimer's. However, genetic factors alone do not determine disease onset; environmental and lifestyle factors also contribute. Research continues to uncover new genetic variants and pathways involved in Alzheimer's, aiding in earlier diagnosis and potential therapeutic targets. Understanding these genetic foundations is crucial for developing personalized treatments and interventions aimed at delaying or preventing the disease.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States