Alzheimer's disease, a progressive neurodegenerative disorder, currently lacks a cure but several medications aim to alleviate symptoms and slow progression. Cholinesterase inhibitors, such as donepezil, rivastigmine, and galantamine, enhance communication among brain cells by preserving acetylcholine, a neurotransmitter crucial for memory and learning. Another class, NMDA receptor antagonists like memantine, regulates glutamate activity to mitigate symptoms like confusion and memory loss. Emerging research explores potential treatments targeting amyloid plaques and tau tangles, hallmark brain abnormalities in Alzheimer's. These include monoclonal antibodies like aducanumab, designed to clear amyloid plaques, and tau-targeting therapies. While these treatments offer hope, ongoing research aims to better understand Alzheimer's complex mechanisms to develop more effective therapies.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States