Alzheimer's disease, a form of dementia, is characterized by distinct neuropathological changes in the brain. These include the accumulation of beta-amyloid plaques outside neurons and neurofibrillary tangles composed of tau protein inside neurons. Beta-amyloid plaques disrupt communication between brain cells, while tau tangles contribute to cell death and tissue loss, particularly in areas crucial for memory and cognitive function, such as the hippocampus and cerebral cortex. These pathological features lead to progressive cognitive decline, memory loss, and eventually, challenges in daily functioning. Understanding these neuropathological changes is crucial for developing effective treatments and interventions to manage Alzheimer's disease and improve quality of life for affected individuals.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States