Amyloid Beta

Amyloid beta (Aβ) is a peptide implicated in Alzheimer's disease and other forms of dementia. It forms when amyloid precursor protein (APP) is improperly cleaved by enzymes. Accumulating Aβ peptides aggregate into plaques, a hallmark of Alzheimer's pathology. These plaques disrupt cell function, trigger inflammation, and promote neuronal death, contributing to cognitive decline and memory loss. Research aims to understand the mechanisms of Aβ formation and aggregation, seeking therapeutic strategies to prevent or reduce plaque buildup. Despite its central role in Alzheimer’s, the exact relationship between amyloid beta and disease progression remains complex, involving genetic, environmental, and biochemical factors.