Amyloid-Beta Precursor Protein
Amyloid-Beta Precursor Protein (APP) plays a central role in Alzheimer's Disease and dementia. APP is a transmembrane protein found in neural tissue. It is cleaved by enzymes into smaller fragments, including amyloid-beta (Aβ) peptides. Accumulation of Aβ peptides forms plaques, a hallmark of Alzheimer's pathology. These plaques disrupt cell communication and trigger inflammatory responses, contributing to neurodegeneration. Mutations in the APP gene can increase the production of Aβ, leading to early-onset familial Alzheimer's. Understanding APP's function and its cleavage pathways is crucial for developing therapeutic strategies to prevent or reduce amyloid plaque formation, potentially altering the course of Alzheimer's disease.
Committee Members
Jun Hua
Johns Hopkins University , United States
Nazneen N Dewji
Cenna Biosciences Inc, United States
Jacqueline London
Paris Diderot University, FranceSubmit your abstract Today
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Zhenhuan Liu, Guangzhou University of Chinese Medicine, China
Title : Neuromodulation of scalp electroacupuncture in the treatment of autism spectrum disorder
Zhenhuan Liu, Guangzhou University of Chinese Medicine, China
Title : Make a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
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Yun Ju Hsieh, Taipei City Hospital, Taiwan
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Mohamed Abdilahi Duale, Somali Red Crescent Society, Somalia
Title : Imaging brain clearance in Alzheimer’s disease
Jun Hua, Johns Hopkins University , United States