Amyloid-Beta Precursor Protein
Amyloid-Beta Precursor Protein (APP) plays a central role in Alzheimer's Disease and dementia. APP is a transmembrane protein found in neural tissue. It is cleaved by enzymes into smaller fragments, including amyloid-beta (Aβ) peptides. Accumulation of Aβ peptides forms plaques, a hallmark of Alzheimer's pathology. These plaques disrupt cell communication and trigger inflammatory responses, contributing to neurodegeneration. Mutations in the APP gene can increase the production of Aβ, leading to early-onset familial Alzheimer's. Understanding APP's function and its cleavage pathways is crucial for developing therapeutic strategies to prevent or reduce amyloid plaque formation, potentially altering the course of Alzheimer's disease.
Committee Members
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan Dementia 2023 Speakers
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States