Amyloid-Beta Precursor Protein
Amyloid-Beta Precursor Protein (APP) plays a central role in Alzheimer's Disease and dementia. APP is a transmembrane protein found in neural tissue. It is cleaved by enzymes into smaller fragments, including amyloid-beta (Aβ) peptides. Accumulation of Aβ peptides forms plaques, a hallmark of Alzheimer's pathology. These plaques disrupt cell communication and trigger inflammatory responses, contributing to neurodegeneration. Mutations in the APP gene can increase the production of Aβ, leading to early-onset familial Alzheimer's. Understanding APP's function and its cleavage pathways is crucial for developing therapeutic strategies to prevent or reduce amyloid plaque formation, potentially altering the course of Alzheimer's disease.
Committee Members
Jun Hua
Johns Hopkins University , United States
Nazneen N Dewji
Cenna Biosciences Inc, United States
Jacqueline London
Paris Diderot University, FranceSubmit your abstract Today
Title : Make a difference
Jacqueline Tuppen, Dementia UK, United Kingdom
Title : Imaging brain clearance in Alzheimer’s disease
Jun Hua, Johns Hopkins University , United States
Title : Neuromodulation of scalp electroacupuncture in the treatment of autism spectrum disorder
Zhenhuan Liu, Nanhai Maternity and Children Hospital Affiliated to Guangzhou University of Chinese Medicine, China
Title : Neuroimaging-based evaluation of scalp acupuncture for neural repair and reorganization in children with cerebral palsy
Zhenhuan Liu, Nanhai Maternity and Children Hospital Affiliated to Guangzhou University of Chinese Medicine, China
Title : Neurophysiological change and cognitive response to levetiracetam in Alzheimer disease: Testing the missing mechanistic link
Christopher Hubler, Emergent Neural Systems Institute for Research, United States
Title : Healthcare professionals in Somaliland had low levels of knowledge and attitudes towards dementia care: A pilot survey
Mohamed Abdilahi Duale, Frantz Fanon University, Somalia