Apoe Alzheimer

APOE, or apolipoprotein E, is a gene closely linked to Alzheimer's disease (AD). It comes in three primary variants: APOE ε2, APOE ε3, and APOE ε4. APOE ε4, in particular, significantly raises the risk of developing late-onset Alzheimer's. Having one copy of APOE ε4 increases susceptibility, while having two copies further heightens this risk. This gene variant influences how the brain processes fats and plays a role in the accumulation and clearance of amyloid-beta plaques, which are characteristic of AD. Researchers are actively exploring how APOE ε4 contributes to Alzheimer's pathology, aiming to develop targeted therapies that address its impact on disease progression.

Committee Members
Speaker at Alzheimer’s Disease, Dementia & Cognitive Disorders Conference 2027 - Jun Hua

Jun Hua

Johns Hopkins University , United States
Speaker at Alzheimer’s Disease, Dementia & Cognitive Disorders Conference 2027 - Nazneen N Dewji

Nazneen N Dewji

Cenna Biosciences Inc, United States
Speaker at Alzheimer’s Disease, Dementia & Cognitive Disorders Conference 2027 - Jacqueline London

Jacqueline London

Paris Diderot University, France

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