Apoe Alzheimer
APOE, or apolipoprotein E, is a gene closely linked to Alzheimer's disease (AD). It comes in three primary variants: APOE ε2, APOE ε3, and APOE ε4. APOE ε4, in particular, significantly raises the risk of developing late-onset Alzheimer's. Having one copy of APOE ε4 increases susceptibility, while having two copies further heightens this risk. This gene variant influences how the brain processes fats and plays a role in the accumulation and clearance of amyloid-beta plaques, which are characteristic of AD. Researchers are actively exploring how APOE ε4 contributes to Alzheimer's pathology, aiming to develop targeted therapies that address its impact on disease progression.
Committee Members
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan Dementia 2023 Speakers
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States