Apoe Alzheimer

APOE, or apolipoprotein E, is a gene closely linked to Alzheimer's disease (AD). It comes in three primary variants: APOE ε2, APOE ε3, and APOE ε4. APOE ε4, in particular, significantly raises the risk of developing late-onset Alzheimer's. Having one copy of APOE ε4 increases susceptibility, while having two copies further heightens this risk. This gene variant influences how the brain processes fats and plays a role in the accumulation and clearance of amyloid-beta plaques, which are characteristic of AD. Researchers are actively exploring how APOE ε4 contributes to Alzheimer's pathology, aiming to develop targeted therapies that address its impact on disease progression.