The Apolipoprotein E (APOE) gene plays a significant role in Alzheimer's disease and dementia. It encodes a protein involved in lipid transport and neurorepair in the brain. There are three common forms of the APOE gene: APOE ε2, APOE ε3, and APOE ε4. Of these, APOE ε4 is the most established genetic risk factor for late-onset Alzheimer's disease. Individuals who inherit one copy of APOE ε4 have an increased risk, while those with two copies have an even higher risk. APOE ε4 is thought to contribute to Alzheimer's by influencing amyloid beta aggregation and clearance, as well as neuroinflammation and neuronal injury. Understanding the role of APOE in Alzheimer's helps in identifying those at higher risk and developing targeted therapies aimed at delaying or preventing the onset of the disease.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States