Apoptosis In Alzheimers Disease

Apoptosis, or programmed cell death, plays a critical role in Alzheimer's disease (AD) pathogenesis. In AD, neurons undergo apoptosis due to various factors, including accumulation of beta-amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. These abnormalities disrupt cellular function and lead to neuronal death, contributing to the progressive cognitive decline observed in AD patients. Understanding the mechanisms of apoptosis in AD is crucial for developing therapeutic strategies aimed at preserving neuronal integrity and slowing disease progression. Research focuses on interventions that can modulate apoptotic pathways to protect neurons from degeneration, offering hope for future treatments that may alleviate symptoms and improve quality of life for those affected by this devastating neurodegenerative disorder.