Apoptosis, or programmed cell death, plays a crucial role in Alzheimer's disease and dementia. In these neurodegenerative conditions, apoptosis pathways are dysregulated, leading to excessive neuronal loss. Alzheimer's is characterized by the accumulation of amyloid-beta plaques and tau tangles, which trigger apoptosis through various mechanisms, including oxidative stress and mitochondrial dysfunction. Apoptosis in dementia contributes to progressive cognitive decline and memory loss as neurons die off irreversibly. Understanding and potentially modulating apoptosis pathways represent promising avenues for therapeutic intervention in managing Alzheimer's and related dementias, aiming to preserve neuronal function and slow disease progression.
Jun Hua
Johns Hopkins University , United States
Nazneen N Dewji
Cenna Biosciences Inc, United States
Jacqueline London
Paris Diderot University, FranceSubmit your abstract Today
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