Apoptosis, or programmed cell death, plays a crucial role in Alzheimer's disease and dementia. In these neurodegenerative conditions, apoptosis pathways are dysregulated, leading to excessive neuronal loss. Alzheimer's is characterized by the accumulation of amyloid-beta plaques and tau tangles, which trigger apoptosis through various mechanisms, including oxidative stress and mitochondrial dysfunction. Apoptosis in dementia contributes to progressive cognitive decline and memory loss as neurons die off irreversibly. Understanding and potentially modulating apoptosis pathways represent promising avenues for therapeutic intervention in managing Alzheimer's and related dementias, aiming to preserve neuronal function and slow disease progression.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States