Estrogen, a hormone primarily involved in female reproductive health, has been linked to Alzheimer's disease (AD) and dementia. Research suggests that estrogen has neuroprotective properties, potentially reducing the risk of AD. It influences brain function by promoting synaptic plasticity, enhancing cerebral blood flow, and reducing inflammation. Postmenopausal women, who experience a significant drop in estrogen levels, show a higher incidence of AD, implying a connection between estrogen deficiency and cognitive decline. Hormone replacement therapy (HRT) has been explored as a preventive measure; however, its efficacy and safety remain controversial, with studies showing mixed results. Understanding estrogen's role in neuroprotection could lead to new therapeutic strategies for combating Alzheimer's and other dementias.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States