Genetic factors play a crucial role in Alzheimer's disease (AD) and dementia, influencing susceptibility and age of onset. The apolipoprotein E (APOE) gene, especially APOE ε4 allele, is the most established genetic risk factor, significantly increasing the likelihood of developing AD. Individuals inheriting one copy of APOE ε4 have a higher risk, while those with two copies face an even greater risk. Beyond APOE, research continues to identify other genetic variations contributing to AD, albeit with less certainty than APOE. These findings underscore the complex interplay of genetic predisposition and environmental factors in the pathogenesis of Alzheimer's. Understanding these genetic underpinnings is critical for developing targeted therapies and advancing personalized medicine approaches in the fight against this debilitating neurodegenerative disease.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States