Neurofibrillary tangles (NFTs) are a hallmark of Alzheimer's disease and other dementias, characterized by twisted fibers inside brain cells. These tangles primarily consist of a protein called tau, which normally helps maintain the structure of neurons. In Alzheimer's, tau proteins become abnormal and clump together, disrupting neuronal function and communication. This leads to cell death and contributes to the cognitive decline seen in affected individuals. NFTs are found predominantly in areas of the brain involved in memory and cognitive functions. Understanding their formation and impact is crucial for developing therapies to combat Alzheimer's disease and related dementias, aiming to alleviate symptoms and slow down progression by targeting these pathological changes in the brain.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States