Oxidative stress plays a pivotal role in the pathogenesis of Alzheimer's disease and dementia. It arises from an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify these harmful compounds. In Alzheimer's, oxidative stress contributes to neuronal damage through lipid peroxidation, DNA oxidation, and protein oxidation, exacerbating amyloid-beta (Aβ) aggregation and tau hyperphosphorylation. This cellular damage impairs synaptic function and accelerates neurodegeneration. Moreover, oxidative stress disrupts mitochondrial function, further elevating ROS levels and perpetuating a vicious cycle of neuronal injury. Therapeutic strategies targeting oxidative stress, such as antioxidants, aim to mitigate these effects and slow the progression of neurodegenerative diseases.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States