The paleomammalian cortex, part of the limbic system, plays a crucial role in emotional regulation and memory processing. In Alzheimer's disease and dementia, the degeneration of the paleomammalian cortex significantly impacts these functions. Neurofibrillary tangles and amyloid plaques disrupt the connectivity within this region, leading to the hallmark symptoms of memory loss and emotional instability. This degeneration contributes to the early and profound impairments seen in patients, affecting their ability to form new memories and manage emotions. Understanding the specific vulnerabilities of the paleomammalian cortex in these conditions can offer insights into potential therapeutic targets aimed at preserving its function and mitigating cognitive and emotional decline.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
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