Dementia, including Alzheimer's Disease, arises from complex pathogenic processes in the brain. In Alzheimer's Disease, abnormal protein deposits, such as beta-amyloid plaques and tau tangles, disrupt neuronal communication and lead to cell death. These changes primarily affect regions involved in memory and cognition, gradually impairing cognitive functions like reasoning, memory recall, and behavior control. Additionally, inflammation, oxidative stress, and genetic factors contribute to the disease's progression. Early symptoms often include forgetfulness and difficulty with familiar tasks, progressing to profound memory loss and personality changes. Understanding these mechanisms is crucial for developing therapies aimed at slowing or halting the progression of dementia, addressing both the cognitive and emotional challenges faced by individuals and their caregivers.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States