Estrogen has garnered attention in Alzheimer's disease (AD) and dementia research due to its potential neuroprotective effects. Observational studies suggest that estrogen may help in preserving cognitive function and reducing AD risk in postmenopausal women. Estrogen's influence on brain health includes the modulation of synaptic plasticity, reduction of amyloid-beta deposition, and anti-inflammatory properties. However, clinical trials on hormone replacement therapy (HRT) have produced mixed results, with some indicating benefits and others suggesting no effect or increased risks. These inconsistencies highlight the need for more personalized approaches, considering factors like timing, dosage, and individual risk profiles, to better understand estrogen's role in AD prevention and treatment.
Jacqueline Tuppen
Cogs Club, United Kingdom
Yong Xiao Wang
Albany Medical College, United States
Kaoru Sakatani
The University of Tokyo, Japan
Suren A Tatulian
University of Central Florida, United States
Constantina Mizis
The Latino Alzheimer’s and Memory Disorders Alliance, United States
Paul Y Song
NKGen Biotech, United States
Marco Ruggiero
Silver Spring Sagl, Switzerland
Title : Cerebral vascular calcium signaling in diabetic alzheimer's disease-related dementias
Yong Xiao Wang, Albany Medical College, United States
Title : Deep learning-based risk assessment of cognitive impairment using health examination data
Kaoru Sakatani, The University of Tokyo, Japan
Title : Evaluation of the neuroprotective potential of indicaxanthin from opuntia ficus indica fruit against dysmetabolism-related neurodegeneration both in vivo and in vitro
Mario Allegra, University of Palermo, Italy
Title : Cogs Club: Making a difference
Jacqueline Tuppen, Cogs Club, United Kingdom
Title : Development of imaging based biomarkers for neurovascular abnormalities in neurodegenerative diseases
Jun Hua, Johns Hopkins University School of Medicine, United States
Title : Psychosocial considerations in management of corticobasal degeneration
Esraa Askar, Forest Hills Hospital, United States