Estrogen has garnered attention in Alzheimer's disease (AD) and dementia research due to its potential neuroprotective effects. Observational studies suggest that estrogen may help in preserving cognitive function and reducing AD risk in postmenopausal women. Estrogen's influence on brain health includes the modulation of synaptic plasticity, reduction of amyloid-beta deposition, and anti-inflammatory properties. However, clinical trials on hormone replacement therapy (HRT) have produced mixed results, with some indicating benefits and others suggesting no effect or increased risks. These inconsistencies highlight the need for more personalized approaches, considering factors like timing, dosage, and individual risk profiles, to better understand estrogen's role in AD prevention and treatment.
Jun Hua
Johns Hopkins University , United States
Nazneen N Dewji
Cenna Biosciences Inc, United States
Jacqueline London
Paris Diderot University, FranceSubmit your abstract Today
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